Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions

Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions

OBJECTIVE Whether distal inflammation in asthmatics also leads to structural changes in the alveolar parenchyma remains poorly examined, especially in patients with uncontrolled asthma. We hypothesized that patients who do not respond to conventional inhaled corticosteroid therapy have a distinct tissue composition, not only in central, but also in distal lung. METHODS Bronchial and transbron...

Matrix Compositions

In this paper we study the class of m-row matrix compositions (m-compositions, for short), i.e., m-row matrices with nonnegative integer entries in which every column has at least one non-zero element. We provide several enumerative results, various combinatorial identities, and some combinatorial interpretations. Most of these properties are an extension to matrix compositions of the combinato...

Guidelines for severe uncontrolled asthma.

Since the publication, 9 years ago, of the latest SEPAR (Spanish Society of Pulmonology and Thoracic Surgery) Guidelines on Difficult-to-Control Asthma (DCA), much progress has been made in the understanding of asthmatic disease. These new data need to be reviewed, analyzed and incorporated into the guidelines according to their level of evidence and recommendation. Recently, consensus document...

A case of uncontrolled asthma

A 48-year-old female patient with uncontrolled severe asthma was referred to our hospital for anti-IgE therapy. She was suffering with persistent wheezing and dyspnea after a severe asthma attack that had taken place 5 months previously. Her asthma had not been controlled with adequate asthma treatment, including budesonide at 320 μg + formoterol at 9 μg b.i.d. combination, montelukast at 10 mg...

Compositions With m Distinct Parts